Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos.Levin, Michael.
Chernet, Brook T.
In addition to the immediate microenvironment, long-range signaling may be an important component of cancer. Molecular-genetic analyses have implicated gap junctions—key mediators of cell-cell communication—in carcinogenesis. We recently showed that the resting voltage potential of distant cell groups is a key determinant of metastatic transformation and tumor induction. Here, we show in the Xenop... read more
- Tufts University. Department of Biology.
- Permanent URL
- Original publication
- Chernet BT, Fields C and Levin M (2015) Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos. Front. Physiol. 5:519. doi: 10.3389/fphys.2014.00519.