Histone deacetylase activity is necessary for leftright patterning during vertebrate development.Levin, Michael.
Karger, Barry L., 1939-
Barisone, Gustavo A.
Lemire, Joan M.
Background: Consistent asymmetry of the left-right (LR) axis is a crucial aspect of vertebrate embryogenesis. Asymmetric gene expression of the TGFβ superfamily member Nodal related 1 (Nr1) in the left lateral mesoderm plate is a highly conserved step regulating the situs of the heart and viscera. In Xenopus, movement of maternal serotonin (5HT) through gap-junctional paths at cleavage stages dict... read more
- Developmental neurobiology.
- Tufts University. Department of Biology.
- Permanent URL
- Original publication
- Carneiro et al.: Histone deacetylase activity is necessary for left-right patterning during vertebrate development. BMC Developmental Biology 2011 11:29. doi:10.1186/1471-213X-11-29.