Metabolic Flux-Based Modularity using Shortest Retroactive distances.Hassoun, Soha.
Sridharan, Gautham Vivek.
Background: Graph-based modularity analysis has emerged as an important tool to study the functional organization of biological networks. However, few methods are available to study state-dependent changes in network modularity using biological activity data. We develop a weighting scheme, based on metabolic flux data, to adjust the interaction distances in a reaction-centric graph model of a meta... read more