In Vitro Model of Metastasis to Bone Marrow Mediates Prostate Cancer Castration Resistant Growth through Paracrine and Extracellular Matrix Factors.

Kaplan, David, 1953-
Lescarbeau, Reynald M.
Seib, F. Philipp.
Prewitz, Marina.
Werner, C. (Carsten)
2012

The spread of prostate cancer cells to the bone marrow microenvironment and castration resistant growth are key steps in disease progression and significant sources of morbidity. However, the biological significance of mesenchymal stem cells (MSCs) and bone marrow derived extracellular matrix (BM-ECM) in this process is not fully understood. We therefore established an in vitro engineered bone mar... read more

Subjects
Tissue engineering.
Prostate--Cancer.
Tufts University. Department of Biomedical Engineering.
Permanent URL
http://hdl.handle.net/10427/009268
Original publication
Lescarbeau RM, Seib FP, Prewitz M, Werner C, Kaplan DL (2012) In Vitro Model of Metastasis to Bone Marrow Mediates Prostate Cancer Castration Resistant Growth through Paracrine and Extracellular Matrix Factors. PLoS ONE 7(8): e40372. doi:10.1371/journal.pone.0040372.
ID: tufts:17835
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