Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.

Kaplan, David, 1953-
Özkucur, Nurdan.
Quinn, Kyle P.
Pang, Jin C.
Du, Chuang.
Georgakoudi, Irene.
Miller, Eric L.
Levin, Michael.
2015

Background: The disruption of neuron arrangement is associated with several pathologies. In contrast to action potentials, the role of resting potential (Vmem) in regulating connectivity remains unknown. Methods: Neuron assemblies were quantified when their Vmem was depolarized using ivermectin (Ivm), a drug that opens chloride channels, for 24 h in cocultures with astrocytes. Cell aggregation was... read more

Subjects
Neurons.
Tufts University. Department of Biomedical Engineering.
Permanent URL
http://hdl.handle.net/10427/009266
Original publication
Özkucur, N., K. P. Quinn, J. C. Pang, C. Du, I. Georgakoudi, E. Miller, M. Levin and D. L. Kaplan (2015). "Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures." Brain and Behavior 5(1): 24-38. doi: 10.1002/brb3.295.
ID: tufts:17830
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