Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.Kaplan, David, 1953-
Quinn, Kyle P.
Pang, Jin C.
Miller, Eric L.
Background: The disruption of neuron arrangement is associated with several pathologies. In contrast to action potentials, the role of resting potential (Vmem) in regulating connectivity remains unknown. Methods: Neuron assemblies were quantified when their Vmem was depolarized using ivermectin (Ivm), a drug that opens chloride channels, for 24 h in cocultures with astrocytes. Cell aggregation was... read more
- Tufts University. Department of Biomedical Engineering.
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- Original publication
- Özkucur, N., K. P. Quinn, J. C. Pang, C. Du, I. Georgakoudi, E. Miller, M. Levin and D. L. Kaplan (2015). "Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures." Brain and Behavior 5(1): 24-38. doi: 10.1002/brb3.295.