Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation.

Muchir, Antoine.
Kim, Young Jin.
Reilly, Sarah A.
Wu, Wei.
Choi, Jason C.
Worman, Howard J.
2013

Background: Autosomal Emery-Dreifuss muscular dystrophy is caused by mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. Classically, the disease manifests as scapulo-humeroperoneal muscle wasting and weakness, early joint contractures and dilated cardiomyopathy wi... read more

Permanent URL
http://hdl.handle.net/10427/010103
Original publication
Muchir, Antoine, Young Jin Kim, Sarah A. Reilly, Wei Wu, Jason C. Choi, and Howard J. Worman. "Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation." Skeletal Muscle 3, no. 1 (12, 2013): 1-10.
ID: tufts:17586
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