| Description |
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Background: The BLM DNA helicase plays a vital role in maintaining
genome stability. Mutations in BLM cause Bloom syndrome, a rare disorder associated
with cancer predisposition and premature aging. Humans and mice with blm mutations
have increased frequencies of spontaneous mutagenesis, but the molecular basis of
this increase is not well ... read moreunderstood. In addition, the effect of aging on spontaneous
mutagenesis in blm mutants has not been characterized. To address this, we used a
lacZ reporter system in wild-type and several mutant strains of Drosophila
melanogaster to analyze mechanisms of mutagenesis throughout their
lifespan.
Keywords: classical non homologous end joining, Drosophila melanogaster
Blm, double-strand break, homologous recombination, DNA ligase 4.
Springer Open.read less
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| Citation |
- Garcia, Ana, Robert N. Salomon, Alice Witsell, Justine
Liepkalns, R. Brent Calder, Moonsook Lee, Martha Lundell, Jan Vijg, and Mitch McVey.
"Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome
rearrangements and tumorigenesis in aging Drosophila." Genome Biology 12, no. 13 (12,
2011): 1-7.
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