Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.Garcia, Ana Maria.
Salomon, Robert N.
Calder, R Brent.
Background: The BLM DNA helicase plays a vital role in maintaining genome stability. Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. Humans and mice with blm mutations have increased frequencies of spontaneous mutagenesis, but the molecular basis of this increase is not wel... read more
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- Garcia, Ana, Robert N. Salomon, Alice Witsell, Justine Liepkalns, R. Brent Calder, Moonsook Lee, Martha Lundell, Jan Vijg, and Mitch McVey. "Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila." Genome Biology 12, no. 13 (12, 2011): 1-7.