Abstract: With the recent addition of anti-angiogenic agents to cancer
treatment, the angiogenesis regulators in platelets are gaining importance. Platelet
factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two
platelet-associated chemokines that modulate tumor angiogenesis, inflammation within
the tumor ... read moremicroenvironment, and in turn tumor growth. Here, we review the role of
PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical
trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer
biomarkers.
Pilatova, Katerina, Kristina Greplova, Regina Demlova, Beatrix
Bencsikova, Giannoula Lakka Klement, and Lenka Zdrazilova-Dubska. "Role of platelet
chemokines, PF-4 and CTAP-III, in cancer biology." Journal of Hematology &
Oncology 6, no. 1 (12, 2013): 1-8.