Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade.

Zawada, W Michael.
Banninger, Gregg P.
Thornton, Jennifer.
Marriott, Beth.
Cantu, David.
Rachubinski, Angela L.
Das, Mita.
Griffin, W Sue.
Jones, Susan M.
2011

Background: Reactive oxygen species (ROS), superoxide and hydrogen peroxide (H2O2), are necessary for appropriate responses to immune challenges. In the brain, excess superoxide production predicts neuronal cell loss, suggesting that Parkinson's disease (PD) with its wholesale death of dopaminergic neurons in substantia nigra pars compact... read more

Permanent URL
http://hdl.handle.net/10427/010065
Original publication
Zawada, W, Gregg P. Banninger, Jennifer Thornton, Beth Marriott, David Cantu, Angela L. Rachubinski, Mita Das, W. Sue Griffin, and Susan M. Jones. "Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade." Journal of Neuroinflammation 8, no. 1 (12, 2011): 1-13.
ID: tufts:17506
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