Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice.Sheoran, Abhineet.
Background: Hemolytic uremic syndrome (HUS) leading to acute kidney failure, is a condition linked to the production of primarily Shiga toxin 2 (Stx2) by some E. coli serotypes. We have previously shown that Stx2 A subunit-specific human monoclonal antibody (HuMAb) 5C12, and B subunit-specific HuMAb 5H8 inhibit cultured cell death, and pr... read more
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- Sheoran, Abhineet, Kwang-il Jeong, Jean Mukherjee, Anthony Wiffin, Pradeep Singh, and Saul Tzipori. "Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice." BMC Immunology 13, no. 1 (12, 2012): 1-8.